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KMID : 0616120180490020182
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Korean Journal of Pharmacognosy
2018 Volume.49 No. 2 p.182 ~ p.187
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The Effects of MeOH Extract of Hopea chinensis (Merr.) Hand.-Mazz. on the Metabolism of Amyloid Precursor Protein in Neuroblastoma Cells
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Shrestha Abinash Chandra
Kim Ju-Eun
Ham Ha-Neul
Jo Youn-Jeong
Tran The Bach
Eum Sang-Mi
Leem Jae-Yoon
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Abstract
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Many plant derived phytochemicals have been considered as the main therapeutic strategy against Alzheimer’s disease (AD). AD is a progressive neurodegenerative disorder, and the most predominant cause of dementia in the elderly. Cholinergic deficit, senile plaque/β-amyloid (Aβ) peptide deposition and oxidative stress have been identified as three main pathogenic pathways which contribute to the progression of AD. We screened many different plant species for their effective use in both modern and traditional system of medicines. In this study, we tested that MeOH extract of the stem bark of Hopea chinensis (Merr.) Hand.-Mazz. (HCM) affects on the processing of Amyloid precursor portein (APP) from the APPswe overexpressing Neuro2a cell line. We showed that HCM reduced the secretion level of Aβ42 and Aβ40 in a dose dependent manner. We found that HCM increased over 1.5 folds of the secretion level of sAPPα, a metabolite of α-secretase. Furthermore, we found that HCM inhibited acetylcholinesterase activity in vitro. We suggest that the stem bark of Hopea chinensis may be a useful source to develop a therapeutics for AD.
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KEYWORD
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Hopea chinensis (Merr.) Hand.-Mazz., Alzheimer’s disease, β-amyloid, Acetylcholinesterase, APPswe, sAPPα
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